边陲小镇长大的乔妍（赵丽颖 饰）打拼多年之后成为了一名知名演员，但在重重压力之下，一路走来小心翼翼。随着一条匿名的勒索消息，让一桩尘封往事成为她新的阴影。同时，多年前失联的姐姐（辛芷蕾 饰）突然现身，事情看似巧合，但背后又暗藏更大的危机。 影片改编自张悦然的小说《大乔小乔》。
MY DEAD FRIEND ZOE is a dark comedy drama that follows the journey of Merit, a U.S. Army Afghanistan veteran who is at odds with her family thanks to the presence of Zoe, her dead best friend from the Army. Despite the persistence of her VA group counselor, the tough love of her mother and the levity of an unexpected love interest, Merit's cozy-dysfunctional friendship with Zoe...
一架满载游客的飞机起飞后突然起火，坠入太平洋深海中，惊魂未定的乘客被困机舱气囊中，氧气已所剩无几，大难不死的乘客以及机组人员正要开始庆祝，却遭到了几只嗜血鲨鱼的袭击，在深不见底的太平洋，鲨鱼群对他们展开凶猛的攻击，求生心切，幸存者们展开了人鲨大战。
